Jan 8, 2007

An Intro to Proteins & Biochemistry

A list of free online books with their relevant chapters of interest.
*direct links to the individual chapters where necessary will be added as time permits*


1.3. Chemical Bonds in Biochemistry

Protein Structure and Function
  • 3.1. Proteins Are Built from a Repertoire of 20 Amino Acids
  • 3.2. Primary Structure: Amino Acids Are Linked by Peptide Bonds to Form Polypeptide Chains
  • 3.3. Secondary Structure: Polypeptide Chains Can Fold Into Regular Structures Such as the Alpha Helix, the Beta Sheet, and Turns and Loops
  • 3.4. Tertiary Structure: Water-Soluble Proteins Fold Into Compact Structures with Nonpolar Cores
  • 3.5. Quaternary Structure: Polypeptide Chains Can Assemble Into Multisubunit Structures
  • 3.6. The Amino Acid Sequence of a Protein Determines Its Three-Dimensional Structure

Exploring Proteins
  • 4.1. The Purification of Proteins Is an Essential First Step in Understanding Their Function
  • 4.2. Amino Acid Sequences Can Be Determined by Automated Edman Degradation
  • 4.3. Immunology Provides Important Techniques with Which to Investigate Proteins
  • 4.4. Peptides Can Be Synthesized by Automated Solid-Phase Methods
  • 4.5. Three-Dimensional Protein Structure Can Be Determined by NMR Spectroscopy and X-Ray Crystallography

DNA, RNA, and the Flow of Genetic Information
  • 5.1. A Nucleic Acid Consists of Four Kinds of Bases Linked to a Sugar-Phosphate Backbone
  • 5.2. A Pair of Nucleic Acid Chains with Complementary Sequences Can Form a Double-Helical Structure
  • 5.3. DNA Is Replicated by Polymerases that Take Instructions from Templates
  • 5.4. Gene Expression Is the Transformation of DNA Information Into Functional Molecules
  • 5.5. Amino Acids Are Encoded by Groups of Three Bases Starting from a Fixed Point
  • 5.6. Most Eukaryotic Genes Are Mosaics of Introns and Exons

7.3. Examination of Three-Dimensional Structure Enhances Our Understanding of Evolutionary Relationships

12. Lipids and Cell Membranes
  • 12.1. Many Common Features Underlie the Diversity of Biological Membranes
  • 12.2. Fatty Acids Are Key Constituents of Lipids
  • 12.3. There Are Three Common Types of Membrane Lipids
  • 12.4. Phospholipids and Glycolipids Readily Form Bimolecular Sheets in Aqueous Media
  • 12.5. Proteins Carry Out Most Membrane Processes

23. Protein Turnover and Amino Acid Catabolism
  • 23.1. Proteins Are Degraded to Amino Acids
  • 23.2. Protein Turnover Is Tightly Regulated

28. RNA Synthesis and Splicing
  • 28.1. Transcription Is Catalyzed by RNA Polymerase
  • 28.2. Eukaryotic Transcription and Translation Are Separated in Space and Time
  • 28.3. The Transcription Products of All Three Eukaryotic Polymerases Are Processed
  • 28.4. The Discovery of Catalytic RNA Was Revealing in Regard to Both Mechanism and Evolution

29. Protein Synthesis
  • 29.1. Protein Synthesis Requires the Translation of Nucleotide Sequences Into Amino Acid Sequences
  • 29.2. Aminoacyl-Transfer RNA Synthetases Read the Genetic Code
  • 29.3. A Ribosome Is a Ribonucleoprotein Particle (70S) Made of a Small (30S) and a Large (50S) Subunit
  • 29.4. Protein Factors Play Key Roles in Protein Synthesis
  • 29.5. Eukaryotic Protein Synthesis Differs from Prokaryotic Protein Synthesis Primarily in Translation Initiation


Entry into the Endoplasmic Reticulum: Protein Translocation, Folding and Quality Control
Protein Translocation Across the ER Membrane
Quality Control in the ER
The Unfolded Protein Response (UPR)
ER and Human Health
Protein Misassembly: Macromolecular Crowding and Molecular Chaperones
Inside the Cell
The Principle of Protein Self-Assembly: Yesterday and Today
The Molecular Chaperone Concept
The Problem of Protein Misassembly
Macromolecular Crowding
Stimulation of Misassembly by Crowding Agents
How do Chaperones Combat Misassembly?
The Molecular Chaperone Function


I. Introduction to the Cell: 3. Proteins
  • The Shape and Structure of Proteins
  • Protein Function

II. Basic Genetic Mechanisms 6. How Cells Read the Genome: From DNA to Protein
  • From DNA to RNA
  • From RNA to Protein
  • The RNA World and the Origins of Life


3. Protein Structure and Function
  • 3.1. Hierarchical Structure of Proteins
  • 3.2. Folding, Modification, and Degradation of Proteins
  • 3.3. Functional Design of Proteins
  • 3.4. Membrane Proteins
  • 3.5. Purifying, Detecting, and Characterizing Proteins

3D, rotating samples of some proteins.
-Display options "backbone" and "strand" are a very nice feature.

Moviesof some folding proteins.
-Quicktime Required

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