2007 week 01: Articles in Veterinary Science

ENTIRE CATALOG OF FERRET PROTEINS TO DATE


Isolation of ferret protein promising for cancer, reproductive studies
Although the focus of the study was about pregnancy, there was this interesting general finding.
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The protein -- glucose-6-phosphate isomerase (GPI) -- already is widely known as a highly conserved enzyme occurring in intracellular metabolism, converting sugars in glycolysis in many organisms and humans. "In the domestic ferrets that we studied, we found a unique role for this enzyme as a secreted protein that is essential in the reproductive process," Bahr said. "Interestingly, he same ability to secrete this protein is found in many types of metastatic tumors, suggesting that tumor cells have co-opted this process. The secretion of GPI allows the tumors to find and lock onto receptors to invade healthy tissues." The ability of tumors to spread is similar to the invasive process of implantation.

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